Calcium so you’re able to Phosphorus Proportion, PTH, and you may Limbs Health

Calcium so you’re able to Phosphorus Proportion, PTH, and you may Limbs Health

Kemi VE, Karkkainen MU, Karp HJ, Laitinen KA, Lamberg-Allardt CJ

Prices from the Ray Peat, PhD: “Brand new ratio away from calcium so you’re able to phosphate is important; that’s why dairy and you will cheese are very worthwhile for losing weight, or for stopping putting on weight. If you are not extremely active, low fat dairy and you may parmesan cheese are more effective, given that extra fat calorie consumption commonly necessary.”

“The foods high when you look at the phosphate, according to calcium supplements, try grain, legumes, meats, and you can seafood. Of several waiting dinners consist of extra phosphate. Snacks having a high, safe proportion out-of calcium to phosphate is renders, such as for instance kale, turnip veggies, and you can beet greens, and some good fresh fruit, dairy, and you may cheddar.”

Br J Nutr

“Totally free unsaturated fatty acids activate the pressure hormone, and cortisol blocks oxidization of sugar and you can turns they toward oily acids and you can triglycerides. Remaining cortisol and you can stress reasonable 's the fundamental question. Keeping a high proportion out-of calcium to phosphate helps to oppose the pressure metabolic Renton escort reviews rate.” “Current book try appearing one too-much phosphate can increase pain, cells atrophy, calcification regarding bloodstream, cancer, dementia, and, in general, this new processes from aging.”

2006 Sep;96(3):545-52. Large phosphorus consumption incredibly and you may adversely apply at Ca and you can bone metabolic process inside a serving-created trends inside suit more youthful people. Kemi VE, Karkkainen MU, Lamberg-Allardt CJ. Ca and you can P are each other important nourishment to have bone as they are known to apply at perhaps one of the most important government out-of bones metabolic rate, parathyroid hormones (PTH). As well good-sized an effective P consumption, typical away from West dieting, would-be deleterious to help you bones from the improved PTH hormonal. Few managed amount-response scientific studies are on the results out of large P intake from inside the kid. We read brand new small-term negative effects of five P doses into Ca and bones metabolism into the fourteen healthy female, 20-28 years of age, who have been randomized so you’re able to five regulated data months; thus for each and every studies topic offered as the her very own handle. P complement dosages out-of 0 (placebo), 250, 750 or 1500 mg had been drawn, divided into about three dosages from inside the studies big date. The dishes served was in fact the same during the for every research time and you will offered 495 mg P and 250 mg California. New P doses affected the gel PTH (S-PTH) into the a dose-dependent styles (P=0.0005). There is a decrease in gel ionized Ca attention simply from inside the the best P amount (P=0.004). The fresh new marker out of bone formation, bone-particular alkaline phosphatase, diminished (P=0.05) as well as the bone resorption marker, N-critical telopeptide out-of collagen sorts of We, increased as a result towards the P dosages (P=0.05). It controlled dose-reaction analysis showed that P enjoys a serving-depending influence on S-PTH and you can expands PTH hormonal notably when California consumption is actually lowest. Acutely highest P intake adversely has an effect on limbs k-calorie burning of the coming down bone formation and you may broadening bones resorption, since the expressed by the bone k-calorie burning markers.

20 Oct 1. Increased calcium intake does not completely counteract the effects of increased phosphorus intake on bone: an acute dose-response study in healthy females. A high dietary P intake is suggested to have negative effects on bone through increased parathyroid hormone secretion, as high serum parathyroid hormone (S-PTH) concentration increases bone resorption. In many countries the P intake is 2- to 3-fold above dietary guidelines, whereas Ca intake is too low. This combination may not be optimal for bone health. In a previous controlled study, we found that dietary P dose-dependently increased S-PTH and bone resorption and decreased bone formation. The aim of the present study was to investigate the dose-response effects of Ca intake on Ca and bone metabolism with a dietary P intake higher than recommended. Each of the twelve healthy female subjects aged 21-40 years attended three 24-h study sessions, which were randomized with regard to a Ca dose of 0 (control day), 600 or 1200 mg, and each subject served as her own control. The meals on each study day provided 1850 mg P and 480 mg Ca. S-PTH concentration decreased (P < 0.001) and serum ionized Ca concentration increased (P < 0.001) with increasing Ca doses. The bone formation marker, serum bone-specific alkaline phosphatase, did not differ significantly (P = 0.4). By contrast, the bone resorption marker, urinary N-terminal telopeptide of collagen type I, decreased significantly with both Ca doses (P = 0.008). When P intake was above current recommendations, increased Ca intake was beneficial for bone, as indicated by decreased S-PTH concentration and bone resorption. However, not even a high Ca intake could affect bone formation when P intake was excessive.

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